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Recombinant human GPX1 protein
Recombinant human GPX1 protein
规格:
货期:
编号:TSENZ2279
品牌:Testobio
| 基因名 | GPX1 |
| 英文全称 | glutathione peroxidase 1 |
| 别称 | GPX1; GPXD; GSHPX1; glutathione peroxidase 1 |
| 中文名称 | 谷胱甘肽过氧化物酶1 |
| Uniprot | P07203 |
| GeneID | 2876 |
| 交叉反应(推测) | Human Mouse Rat (Bovine Pig Rabbit Chicken) |
| 氨基酸大小 | 16kDa |
| 表达氨基酸 | 59-203aa |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| Background | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage.Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes.Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity.This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide.It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site.Sec is encoded by the UGA codon, which normally signals translation termination.The 3 UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population.The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women.Alternatively spliced transcript variants and multiple pseudogenes of this gene have been identified. |
| 规格 | 10ug 50ug 100ug 1mg |
