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基因名 | HRAS |
英文全称 | GTPase HRas |
别称 | HRAS;C-BAS/HAS;C-H-RAS;C-HA-RAS1;CTLO;H-RASIDX;HAMSV;HRAS1;RASH1;p21ras;GTPase HRas |
中文名称 | GTP酶Hras |
Uniprot | P01112 |
GeneID | 3265 |
交叉反应(推测) | Human Mouse Rat (Chicken) |
氨基酸大小 | 21kDa |
表达氨基酸 | 1-189aa |
Background | This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses.The products encoded by these genes function in signal transduction pathways.These proteins can bind GTP and GDP, and they have intrinsic GTPase activity.This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus.Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities.Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma.Multiple transcript variants, which encode different isoforms, have been identified for this gene. |
Application | Immunology research |
Derived from | E.coli |
Purification | NI-NTA affinity purification |
Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Purity | Purity≥85% as determined by reducing SDS-PAGE. |
规格 | 10ug 50ug 100ug 1mg |