| 产品名称： | Cunninghamella echinulata (Thaxter) Thaxter var. echinulata |
|---|---|
| 商品货号： | TS171086 |
| Deposited As： | Cunninghamella bainieri Naumov |
| Strain Designations： | 29 CBS 596.68, IMI 199844 |
| Application： | Assay of papaverine
Metabolizes (+/-)N-(n-propyl)amphetamine
Metabolizes pargyline
Metabolizes phencyclidine
Metabolizes selegeline deprenyl
Produces 10-fluro-19-norpredinsolone
Produces 4-phenylphenol 4-hydroxybiphenyl
Produces 9-hydroxyacronycine
Produces imipramine
Transforms N-methylcarbazole
Transforms methoxyamphetamines
Transforms phenazopyridine
Transforms propranolol
Transforms sesquiterpene lactone costunolide
Transforms stemodin
Transforms tranylcypromine
Conversion of acronycine to 9-hydroxy-acronycine
Conversion of biphenyl to 4-hydroxybiphenyl
Transformation of pergolide to pergolide sulfoxide and pergolide sulfone |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | freeze-dried |
| Storage Conditions： | Frozen: -80°C or colder Freeze-Dried: 2°C to 8°C Live Culture: See Propagation Section |
| Type Strain： | no |
| Preceptrol®： | no |
| Comments： | Monooxygenase activity |
| Morphology： | After 7 days on Cornmeal agar at 25°C, colonies off-white, tan or grey, densely floccose. Sporophores erect, branched, terminating in a vesicle; vesicles globose or subglobose. Sporangiola hyaline to orange, evidently echinulate. Zygospores not observed. |
| Medium： | ATCC® Medium 307: Cornmeal agar ATCC® Medium 325: Malt extract agar (Blakeslees formula) ATCC® Medium 336: Potato dextrose agar (PDA) |
| Growth Conditions： | Temperature: 24°C to 26°C
Atmosphere: Typical aerobic |
| Sequenced Data： |
18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence GGTTTCCGTAGGTGAACCTGCGGAAGGATCATTAACTATTGTGGGAAAAGACGTAAAACATCTTTGACCATTAAATCATCCATAATGTGGGTCAAACCACATGCGCAATGTATTATAAGGTGTTATTTAGTTAGCATCTTTTTATTTGTAATATGGCCTTAAAAAAGCCACATTACTAATTTTTTTATACTAAATTAACTGAAAAAACGATTGACCATAATTTATGGTTGTTTAAACAATATATTAACTTATATAAAAACAACTTTCAGCAATGGATCTCTCGGCTTTCGTATCGATGAAGAACGCAGCAAATCGCGATATTTAATGTGATCTGCCTATAGTGAATCATCAAATCTTTGAACGCATCTTGCACCCTATGGTATTCCGTAGGGTACATCTGTTTCAGTACCATTCAAACATCTCCCTCACTCCTTTTTTTACTAAGAGAGAATGAGATCAGAGATAAATTATAAATGGTCCTGGGTAAGCTGTGTATCAAGTCTTTTGACTTTTTACCTGACGGAATTTTATCACTACCCGCCCTTATATCTTAGCGTATAAGCTCGGTGCTAGGAGTTAAAAGCATAGTAAAGAACCTAACTTGCCTTTGTCAGCCTCCTTCCTTTTAGGTTGGAGGACATGATGCGACTGTGGGACGCCCGATTACCCTCGACTTAAATATCTGTTAAGGTAAATTCTTGACTTATCTTTGCAAAAAGGTATGATAGAATTGGCTTTAATGTTTTTACATCTAGAGTTATTCTTTTAGCTCCTGATGGGAGAAAAAAGCACTAGGAATTCTTTGGAAGTCTTTTTGCCTATTTTTCCATTTTTTTGGCCTGAAATCAGATGGGACTACCCGCTGAACTTAAGCATATCATAA D1D2 region of the 28S ribosomal RNA gene ATATCAATAAGCGGAGGAAAAGAAAATAACAATGATTCCCTCAGTAACGGCGAGTGAACAGGGAAAAGCTCAAAGTTGGAACCTGGTGGGCCTAGCCTACCCGGATTGTAAACTAAAGTTTTTGGGTCGTTTAGTCAGCCAGATAAATAAGTCCTCTGGAAAGGGGCGACATAGAGGGTGAAATCCCCGTCTTTGGTCTGAGCATGATTAGGCGTTTGGCCTGGAAACGAAGAGTCAGGTTGTTTGGGAATGCAGCCTAAAATGGGAGGTAAATCTCTCCTAAAGCTAAATATTGACGAAAGACCGATAGCGAACAAGTACCGTGAGGGAAAGATGAAAAGCACTTTGAAAAGAGGGTCAAAAAGTACGTGAAATTGCTGAAAGGGAACCGTATAAAATCAGACTTACTGATAGGTAATCAACCTTCCTCTTGGGGAGGGTGCACTTGCCTGTTATTGTATGCCAGCAATACTTTGGTTGGGAGGAAAAAAGTAGGAGAAATGTAGCCTAGGCTTCGGTTTAGGTGTTATAGTCTTTTGCAAAATACTCTCGGCTGGAGTAAGGAACGCAGCAAACCGTAAGGCGAAGATTTTGGGCGCTTGGAATTAATAGTTGGAGAATTTCTGCTTCGGGTGGTGCTTTAGCTATTAGTTTTAACCCGCTTAAAGTTCTTTTAATTTGCTTAGGTTGTTGGCTTAATGATTTTATATGAC |
| Name of Depositor： | VM Cutter |
| Isolation： | Hibiscus flowers, Ann Arbor, MI |
| References： | Coutts RT, et al. Metabolism of (+ or - )-N-(n-propyl) amphetamine by Cunninghamella echinulata. Appl. Environ. Microbiol. 37: 429-432, 1979. PubMed: 453824 Smith RV, et al. Mechanism of hydroxylation of biphenyl by Cunninghamella echinulata. Biochem. J. 196: 369-371, 1981. PubMed: 7306077 Mills JS. 10-Fluoro-19-nor steroids. US Patent 3,053,858 dated Sep 11 1962 Badria FA, Hufford CD. Microbial transformations of stemodin, a Stemodia diterpene. Phytochemistry 30: 2265-2268, 1991. Yang W, Davis PJ. Microbial models of mammalian metabolism. Biotransformations of N-methylcarbazole using the fungus Cunninghamella echinulata. Drug Metab. Dispos. 20: 38-46, 1992. PubMed: 1346994 Davila JC, et al. Cytotoxicity induced by papaverine hydrochloride in fungal cell systems. Toxicol. Lett. 54: 23-31, 1990. PubMed: 2244336 Foster BC, et al. Aromatic hydroxylation and sulfation of phenazopyridine by Cunninghamella echinulata. Can. J. Microbiol. 37: 504-508, 1991. Foster BC, et al. The biotransformation of tranylcypromine by Cunninghamella echinulata. Can. J. Microbiol. 37: 791-795, 1991. PubMed: 1777857 Ferris JP, et al. Monooxygenase activity in Cunninghamella bainieri: evidence for a fungal system similar to liver microsomes. Arch. Biochem. Biophys. 156: 97-103, 1973. PubMed: 4730481 Hufford CD, et al. Metabolism of phencyclidine by microorganisms. J. Pharm. Sci. 70: 155-158, 1981. PubMed: 7205218 Ferris JP, et al. Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri: evidence for the presence of cytochrome P-450. Arch. Biochem. Biophys. 175: 443-452, 1976. PubMed: 8708 Coutts RT, et al. Fungal metabolism of (-)-deprenyl and pargyline. Life Sci. 29: 1951-1958, 1981. PubMed: 6796795 Foster BC, et al. Biotransformation of 2-, 3-, and 4-methoxy-amphetamines by Cunninghamella echinulata. Xenobiotica 21: 1337-1346, 1991. PubMed: 1796610 Foster BC, et al. In vitro assessment of cytotoxicity and biotransformation of propranolol in Cunninghamella echinulata. Xenobiotica 22: 1221-1228, 1992. PubMed: 1492414 Foster BC, et al. Biotransformation of tri-substituted methoxyamphetamines by Cunninghamella echinulata. Xenobiotica 22: 1383-1394, 1992. PubMed: 1494884 Betts RE, et al. Microbial transformations of antitumor compounds. I. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata. J. Med. Chem. 17: 599-602, 1974. PubMed: 4829940 Clark AM, Hufford CD. Microbial transformations of the sesquiterpene lactone costunolide. J. Chem. Soc. Perkin Trans. 1979: 3022-3028, 1979. Hufford CD, et al. Metabolism of imipramine by microorganisms. J. Pharm. Sci. 70: 151-155, 1981. PubMed: 7205217 Smith RV, et al. Microbial transformations of pergolide to pergolide sulfoxide and pergolide sulfone. J. Pharm. Sci. 72: 733-736, 1983. PubMed: 6684155 |
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| 产品名称： | Cunninghamella echinulata (Thaxter) Thaxter var. echinulata |
|---|---|
| 商品货号： | TS171086 |
| Deposited As： | Cunninghamella bainieri Naumov |
| Strain Designations： | 29 CBS 596.68, IMI 199844 |
| Application： | Assay of papaverine
Metabolizes (+/-)N-(n-propyl)amphetamine
Metabolizes pargyline
Metabolizes phencyclidine
Metabolizes selegeline deprenyl
Produces 10-fluro-19-norpredinsolone
Produces 4-phenylphenol 4-hydroxybiphenyl
Produces 9-hydroxyacronycine
Produces imipramine
Transforms N-methylcarbazole
Transforms methoxyamphetamines
Transforms phenazopyridine
Transforms propranolol
Transforms sesquiterpene lactone costunolide
Transforms stemodin
Transforms tranylcypromine
Conversion of acronycine to 9-hydroxy-acronycine
Conversion of biphenyl to 4-hydroxybiphenyl
Transformation of pergolide to pergolide sulfoxide and pergolide sulfone |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | freeze-dried |
| Storage Conditions： | Frozen: -80°C or colder Freeze-Dried: 2°C to 8°C Live Culture: See Propagation Section |
| Type Strain： | no |
| Preceptrol®： | no |
| Comments： | Monooxygenase activity |
| Morphology： | After 7 days on Cornmeal agar at 25°C, colonies off-white, tan or grey, densely floccose. Sporophores erect, branched, terminating in a vesicle; vesicles globose or subglobose. Sporangiola hyaline to orange, evidently echinulate. Zygospores not observed. |
| Medium： | ATCC® Medium 307: Cornmeal agar ATCC® Medium 325: Malt extract agar (Blakeslees formula) ATCC® Medium 336: Potato dextrose agar (PDA) |
| Growth Conditions： | Temperature: 24°C to 26°C
Atmosphere: Typical aerobic |
| Sequenced Data： |
18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence GGTTTCCGTAGGTGAACCTGCGGAAGGATCATTAACTATTGTGGGAAAAGACGTAAAACATCTTTGACCATTAAATCATCCATAATGTGGGTCAAACCACATGCGCAATGTATTATAAGGTGTTATTTAGTTAGCATCTTTTTATTTGTAATATGGCCTTAAAAAAGCCACATTACTAATTTTTTTATACTAAATTAACTGAAAAAACGATTGACCATAATTTATGGTTGTTTAAACAATATATTAACTTATATAAAAACAACTTTCAGCAATGGATCTCTCGGCTTTCGTATCGATGAAGAACGCAGCAAATCGCGATATTTAATGTGATCTGCCTATAGTGAATCATCAAATCTTTGAACGCATCTTGCACCCTATGGTATTCCGTAGGGTACATCTGTTTCAGTACCATTCAAACATCTCCCTCACTCCTTTTTTTACTAAGAGAGAATGAGATCAGAGATAAATTATAAATGGTCCTGGGTAAGCTGTGTATCAAGTCTTTTGACTTTTTACCTGACGGAATTTTATCACTACCCGCCCTTATATCTTAGCGTATAAGCTCGGTGCTAGGAGTTAAAAGCATAGTAAAGAACCTAACTTGCCTTTGTCAGCCTCCTTCCTTTTAGGTTGGAGGACATGATGCGACTGTGGGACGCCCGATTACCCTCGACTTAAATATCTGTTAAGGTAAATTCTTGACTTATCTTTGCAAAAAGGTATGATAGAATTGGCTTTAATGTTTTTACATCTAGAGTTATTCTTTTAGCTCCTGATGGGAGAAAAAAGCACTAGGAATTCTTTGGAAGTCTTTTTGCCTATTTTTCCATTTTTTTGGCCTGAAATCAGATGGGACTACCCGCTGAACTTAAGCATATCATAA D1D2 region of the 28S ribosomal RNA gene ATATCAATAAGCGGAGGAAAAGAAAATAACAATGATTCCCTCAGTAACGGCGAGTGAACAGGGAAAAGCTCAAAGTTGGAACCTGGTGGGCCTAGCCTACCCGGATTGTAAACTAAAGTTTTTGGGTCGTTTAGTCAGCCAGATAAATAAGTCCTCTGGAAAGGGGCGACATAGAGGGTGAAATCCCCGTCTTTGGTCTGAGCATGATTAGGCGTTTGGCCTGGAAACGAAGAGTCAGGTTGTTTGGGAATGCAGCCTAAAATGGGAGGTAAATCTCTCCTAAAGCTAAATATTGACGAAAGACCGATAGCGAACAAGTACCGTGAGGGAAAGATGAAAAGCACTTTGAAAAGAGGGTCAAAAAGTACGTGAAATTGCTGAAAGGGAACCGTATAAAATCAGACTTACTGATAGGTAATCAACCTTCCTCTTGGGGAGGGTGCACTTGCCTGTTATTGTATGCCAGCAATACTTTGGTTGGGAGGAAAAAAGTAGGAGAAATGTAGCCTAGGCTTCGGTTTAGGTGTTATAGTCTTTTGCAAAATACTCTCGGCTGGAGTAAGGAACGCAGCAAACCGTAAGGCGAAGATTTTGGGCGCTTGGAATTAATAGTTGGAGAATTTCTGCTTCGGGTGGTGCTTTAGCTATTAGTTTTAACCCGCTTAAAGTTCTTTTAATTTGCTTAGGTTGTTGGCTTAATGATTTTATATGAC |
| Name of Depositor： | VM Cutter |
| Isolation： | Hibiscus flowers, Ann Arbor, MI |
| References： | Coutts RT, et al. Metabolism of (+ or - )-N-(n-propyl) amphetamine by Cunninghamella echinulata. Appl. Environ. Microbiol. 37: 429-432, 1979. PubMed: 453824 Smith RV, et al. Mechanism of hydroxylation of biphenyl by Cunninghamella echinulata. Biochem. J. 196: 369-371, 1981. PubMed: 7306077 Mills JS. 10-Fluoro-19-nor steroids. US Patent 3,053,858 dated Sep 11 1962 Badria FA, Hufford CD. Microbial transformations of stemodin, a Stemodia diterpene. Phytochemistry 30: 2265-2268, 1991. Yang W, Davis PJ. Microbial models of mammalian metabolism. Biotransformations of N-methylcarbazole using the fungus Cunninghamella echinulata. Drug Metab. Dispos. 20: 38-46, 1992. PubMed: 1346994 Davila JC, et al. Cytotoxicity induced by papaverine hydrochloride in fungal cell systems. Toxicol. Lett. 54: 23-31, 1990. PubMed: 2244336 Foster BC, et al. Aromatic hydroxylation and sulfation of phenazopyridine by Cunninghamella echinulata. Can. J. Microbiol. 37: 504-508, 1991. Foster BC, et al. The biotransformation of tranylcypromine by Cunninghamella echinulata. Can. J. Microbiol. 37: 791-795, 1991. PubMed: 1777857 Ferris JP, et al. Monooxygenase activity in Cunninghamella bainieri: evidence for a fungal system similar to liver microsomes. Arch. Biochem. Biophys. 156: 97-103, 1973. PubMed: 4730481 Hufford CD, et al. Metabolism of phencyclidine by microorganisms. J. Pharm. Sci. 70: 155-158, 1981. PubMed: 7205218 Ferris JP, et al. Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri: evidence for the presence of cytochrome P-450. Arch. Biochem. Biophys. 175: 443-452, 1976. PubMed: 8708 Coutts RT, et al. Fungal metabolism of (-)-deprenyl and pargyline. Life Sci. 29: 1951-1958, 1981. PubMed: 6796795 Foster BC, et al. Biotransformation of 2-, 3-, and 4-methoxy-amphetamines by Cunninghamella echinulata. Xenobiotica 21: 1337-1346, 1991. PubMed: 1796610 Foster BC, et al. In vitro assessment of cytotoxicity and biotransformation of propranolol in Cunninghamella echinulata. Xenobiotica 22: 1221-1228, 1992. PubMed: 1492414 Foster BC, et al. Biotransformation of tri-substituted methoxyamphetamines by Cunninghamella echinulata. Xenobiotica 22: 1383-1394, 1992. PubMed: 1494884 Betts RE, et al. Microbial transformations of antitumor compounds. I. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata. J. Med. Chem. 17: 599-602, 1974. PubMed: 4829940 Clark AM, Hufford CD. Microbial transformations of the sesquiterpene lactone costunolide. J. Chem. Soc. Perkin Trans. 1979: 3022-3028, 1979. Hufford CD, et al. Metabolism of imipramine by microorganisms. J. Pharm. Sci. 70: 151-155, 1981. PubMed: 7205217 Smith RV, et al. Microbial transformations of pergolide to pergolide sulfoxide and pergolide sulfone. J. Pharm. Sci. 72: 733-736, 1983. PubMed: 6684155 |
